Gueorguieva R., Wu R. Donovan D. et al. ‘Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study’. Drug and Alcohol Dependence: 2010, 107, p. 221–229.
Reanalysis of the largest US study of medication-based alcoholism treatment confirms that either naltrexone or psychological therapy improved outcomes more than medical care and placebos, while the two in combination or acamprosate added little. It also revealed previously invisible benefits when certain types of patients received certain treatments.